The cortical excitability of the primary motor cortex can be significantly influenced by space-occupying lesions such as brain tumors. Recent studies also suggest that there is a link between changes in cortical excitability and possible tumour progression. The aim of this retrospective doctoral project is to systematically investigate this link using existing clinical data. To this end, existing data from over ten years of clinical practice and research will be compiled, processed, and evaluated with regard to its association with tumour progression. Data sets collected using navigated transcranial magnetic stimulation (nTMS) and their clinical correlates from patient records are available. The project thus combines sound scientific work with direct relevance to clinical practice.

Despite the retrospective nature of the study, doctoral students will be trained in the use of nTMS. After successful training, they independently perform nTMS examinations as part of on-call duties, depending on availability, in the absence of our study nurse. This not only serves to improve their understanding of the subject matter, but also actively supports preoperative diagnostics in our clinic, enabling them to become involved in everyday clinical practice and have direct contact with patients.