Outcome after surgical resection of melanoma brain metastases and predictors of outcome

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Outcome after surgical resection of melanoma brain metastases and predictors of outcome

Key Points

Subject area:

Project type:

Timespan:

Location:

University:

Supervisor:

Neurosurgery

Clinical Research

Flexible start; ongoing

On-site

Heinrich Heine University Düsseldorf (HHU)

Dr. med. David Wasilewski

Summary
of the
project:

Short description:Retrospective cohort analysis of patients with surgically resected melanoma brain metastases, focusing on overall survival (OS), progression-free survival (PFS), risk of leptomeningeal disease (LMD), and predictors for postoperative complications and treatment feasibility. Key clinical modifiers include symptom burden (symptomatic vs asymptomatic) and frailty metrics (e.g., CFS / mFI-5).

Co-working tasks (modules):

Structured chart review and data capture (treatments, follow-up, outcomes)
Classification of peri-/postoperative complications (incl. CTCAE-based grading where feasible)
Support with key radiology variables (number/location/size; edema/hemorrhage status) and therapy sequencing
Optional: extraction of available molecular markers (e.g., BRAF/NRAS/c-KIT, PD-L1)

Requirements (helpful):MD student, preferably located near Düsseldorf; reliable and structured working style; basic Excel skills; German helpful for chart review. Prior neuro-oncology/imaging experience is a plus, but not needed.

Output / opportunities:Depending on contribution and results, co-authorship on a manuscript and/or poster presentations(conference submissions) are possible.